Learn more about genomic biomarkers and read the latest CBC publications.

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The publications are sorted by topic:

MicroRNA in diagnosis and therapy monitoring of early-stage triple-negative breast cancer
Kahraman M, Röske A, Laufer T, Fehlmann T, Backes C, et al.
Sci Rep. 2018

Genome-wide microRNA expression profiles in COPD: early predictors for cancer development
Keller A, Fehlmann T, Ludwig N, Kahraman M, Laufer T, et al.
Genomics Proteomics Bioinformatics 2018

A high-resolution map of the human small non-coding transcriptome
Fehlmann T, Backes C, Alles J, Fischer U, Hart M, et al.
Bioinformatics 2017

Web-based NGS data analysis using miRMaster: a large-scale meta-analysis of human miRNAs
Fehlmann T, Backes C, Kahraman M, Haas J, Ludwig N, et al.
Nucleic Acids Res. 2017

Technical Stability and Biological Variability in MicroRNAs from Dried Blood Spots: A Lung Cancer Therapy-Monitoring Showcase
Kahraman M, Laufer T, Backes C, Schrörs H, Fehlmann T, et al.
Clin Chem. 2017

Reading miRNAs for Clinical Meaning
Stein, Richard A.
GEN 2017

Relevance of pre-analytical blood management on the emerging cardiovascular protein biomarkers TWEAK and HMGB1 and on miRNA serum and plasma profiling
Basso D, Padoan A, Laufer T, Aneloni V, Moz S, et al.
Clin Biochem. 2017

PDAC-derived exosomes enrich the microenvironment in MDSCs in a SMAD4-dependent manner through a new calcium related axis
Basso D, Gnatta E, Padoan A, Fogar P, Furlanello S, et al.
Oncotarget 2017

High-throughput qRT-PCR validation of blood microRNAs in non-small cell lung cancer
Leidinger P, Brefort T, Backes C, Krapp M, Galata V, et al.
Oncotarget 2015

miRNAs can be generally associated with human pathologies as exemplified for miR-144
Keller A, Leidinger P, Vogel B, Backes C, ElSharawy A, et al.
BMC Medicine 2014

Natalizumab restores aberrant miRNA expression profile in multiple sclerosis and reveals a critical role for miR-20b
Ingwersen J, Menge T, Wingerath B, Kaya D, Graf J, Prozorovski T, Keller A, Backes C, Beier M, Scheffler M, Dehmel T, Kieseier BC, Hartung H-P, Küry P, Aktas O
Ann Clin Transl Neurol. 2014

Circulating microRNA profiling in patients with advanced non-squamous NSCLC receiving bevacizumab/erlotinib followed by platinum-based chemotherapy at progression (SAKK 19/05)
Joerger M, Baty F, Früh M, Droege C, Stahel RA, Betticher DC, von Moos R, Ochsenbein A, Pless M, Gautschi O, Rothschild S, Brauchli P, Klingbiel D, Zappa F, Brutsche M
Lung Cancer 2014

Ultra deep sequencing of Listeria monocytogenes sRNA transcriptome revealed new antisense RNAs
Behrens S, Widder S, Mannala GK, Qing X, Madhugiri R, Kefer N, Abu Mraheil M, Rattei T, Hain T
PloS ONE 2014

Multivariate miRNA signatures as biomarkers for non-ischaemic systolic heart failure.
Vogel B, Keller A, Frese KS, Leidinger P, Sedaghat-Hamedani F, et al.
Eur Heart J. 2013

miR-20b, miR-98, miR-125b-1*, and let-7e* as new potential diagnostic biomarkers in ulcerative colitis.
Coskun M, Bjerrum JT, Seidelin JB, Troelsen JT, Olsen J, et al.
World J Gastroenterol. 2013

Refining Diagnostic MicroRNA Signatures by Whole-miRNome Kinetic Analysis in Acute Myocardial Infarction
Vogel B, Keller A, Frese K, Kloos W, Kayvanpour E, et al.
Clin Chem. 2013

Intestinal Salmonella typhimurium infection leads to miR-29a induced caveolin 2 regulation
Hoeke L, Sharbati J, Pawar K, Keller A, Einspanier R, Sharbati S
PloS ONE 2013

Treatment-independent miRNA signature in blood of wilms tumor patients
Schmitt J, Backes C, Nourkami-Tutdibi N, Leidinger P, Deutscher S, et al.
BMC Genomics 2012

Temporal- and Strain-Specific Host MicroRNA Molecular Signatures Associated with Swine-Origin H1N1 and Avian-Origin H7N7 Influenza A Virus Infection
Loveday E-K, Svinti V, Diederich S, Pasick J, Jean F
J Virol. 2012

Low Levels of Cell-Free Circulating miR-361-3p and miR-625* as Blood-Based Markers for Discriminating Malignant from Benign Lung Tumors
Roth C, Stückrath I, Pantel K, Izbicki JR, Tachezy M, et al.
PLoS One. 2012

Genome-wide miRNA signatures of human longevity
ElSharawy A, Keller A, Flachsbart F, Wendschlag A, Jacobs G et al.
Aging Cell. 2012

Diagnosis of Pancreatic Ductal Adenocarcinoma and Chronic Pancreatitis by Measurement of microRNA Abundance in Blood and Tissue
Bauer A, Keller A, Costello E, Greenhalf W, Bier M et al.
PLoS One. 2012

microRNA Response to Listeria monocytogenes Infection in Epithelial Cells
Izar B, Mannala GK, Mraheil MA, Chakraborty T, Hain T
Int J Mol Sci. 2012

MiRNA expression patterns predict survival in glioblastoma
Niyazi M, Zehentmayr F, Niemöller OM, Eigenbrod S, Kretschmar H, et al.
Radiat Oncol. 2011

Next-generation sequencing identifies novel microRNAs in peripheral blood of lung cancer patients
Keller A, Backes C, Leidinger P, Kefer N, Boisguerin V, et al.
Mol Biosyst. 2011

Toward the blood-borne miRNome of human diseases
Keller A, Leidinger P, Bauer A, ElSharawy A, Haas J, et al.
J Nature Methods 2011

Cause and Effect
Amarantos I, Laufer T, Brefort T
EBR 2011

Circulating micro-RNAs as Potential Blood-Based Markers for Early Stage Breast Cancer Detection
Schrauder MG, Strick R, Schulz-Wendtland R, Strissel P, Kahmann L, et al.
PloS ONE 2012

A specific miRNA signature in the peripheral blood of glioblastoma patients
Roth P, Wischhusen J, Happold C, Anoop Chandran P, et al.
J Neurochem. 2011

Stable serum miRNA profiles as potential tool for non-invasive lung cancer diagnosis
Keller A, Leidinger P, Gislefoss R, Haugen A, Langseth H, et al.
RNA Biol. 2011

Specific peripheral miRNA profiles for distinguishing lung cancer from COPD
Leidinger P, Keller A, Borries A, Huwer H, Rohling M, et al.
Lung Cancer 2011

The intestinal factor Tff3 and a miRNA network regulate murine caloric metabolism
Shah A, Leidinger P, Keller A, Wendschlag A, Backes C, et al.
RNA Biol. 2011

MicroRNA signatures in total peripheral blood as novel biomarkers for acute myocardial infarction
Meder B, Keller A, Vogel B, Haas J, Sedaghat-Hamedani F, et al.
Basic Research in Cardiology 2011

MicroRNA profiling during cardiomyocyte-specific differentiation of murine embryonic stem cells based on two different miRNA array platforms
Gan L, Schwengberg S, Denecke B
PLoS One 2011

Circulating microRNAs in patients with coronary artery disease
Fichtlscherer S, De Rosa S, Fox H, Schwietz T, Fischer A, et al.
Circ. Res. 2011

Whole blood-derived miRNA profiles as potential new tools for ovarian cancer screening
Häusler S, Keller A, Chandran A, Ziegler K, Zipp K, Heuer S, et al.
British Journal of Cancer 2010

High-throughput miRNA profiling of human melanoma blood samples
Leidinger P, Keller A, Borries A, Reichrath J, Rass K, et al.
BMC Cancer 2010

miRNAs in lung cancer - Studying complex fingerprints in patient's blood cells by microarray experiments
Keller A, Leidinger P, Borries A, Wendschlag A, Wucherpfennig F, et al.
BMC Cancer 2009

Multiple Sclerosis - MicroRNA Expression Profiles Accurately Differentiate Patients with Relapsing-Remitting Disease from Healthy Controls
Keller A, Leidinger P, Lange J, Borries A, Schroers H, et al.
PLoS ONE 2009

Micro-array profiling exhibits remarkable intra-individual stability of human platelet micro-RNA
Stratz C, Nührenberg TG, Binder H, Valina CM, Trenk D, et al.
Thromb Haemost. 2012

Microfluidic primer extension assay
Beier M, Boisguérin V
Methods Mol Biol. 2012

Microfluidic-based enzymatic on-chip labeling of miRNAs
Vorwerk S, Ganter K, Cheng Y, Hoheisel J, Stähler PF and Beier M
New Biotechnology 2008

Small Molecules with Big Impact in Cancer
Beier V, Hoheisel J
BIOforum Europe 2008

Impact of MicroRNAs in Cancer Research
Beier V, Stähler PF
Whitepaper 2008

Altered miRNA expression patterns in Tff2 knock-out mice correlate with cellular pathways of neoplastic development and caloric metabolism
Shah AA, Leidinger P, Keller A, Wendschlag A, Meese E, Blin N
Int J Mol Med. 2012

Targeted next-generation sequencing for the molecular genetic diagnostics of cardiomyopathies
Meder B, Haas J, Keller A, Heid C, Just S, et al.
Circ Cardiovasc Genet. 2011

Identification of novel SNPs in glioblastoma using targeted resequencing
Keller A, Harz C, Matzas M, Meder B, Katus HA, et al.
PLoS One. 2011

Heptahelical receptors GprC and GprD of Aspergillus fumigatus are essential regulators of colony growth, hyphal morphogenesis and virulence
Gehrke A, Heinekamp T, Jacobsen DI and Brakhage AA
Appl. Envir. Microbiol. 2010

ArcS is the cognate sensor kinase in an atypical Arc system of Shewanella oneidensis MR-1
Lassak J, Henche A, Binnenkade L and Thormann KM
Appl. Envir. Microbiol. 2010

Intimate bacterial–fungal interaction triggers biosynthesis of archetypal polyketides in Aspergillus nidulans
Schroeckh V, Scherlach K, Nützmann HW, Shelest E, Schmidt-Heck W, et al.
PNAS 2009

Characterization of the Zoarces viviparus liver transcriptome using massively parallel pyrosequencing.
Kristiansson E, Asker N, Forlin L and Larsson DG
BMC Genomics 2009

A novel algorithm for detecting differentially regulated paths based on gene set enrichment analysis
Keller A, Backes C, Gerasch A, Kaufmann M, Kohlbacher O, et al.
Bioinformatics 2009

Pharmaceutical Industry Effluent Diluted 1:500 Affects Global Gene Expression, Cytochrome P4501A Activity and Plasma Phosphate in Fish
Gunnarsson L, Kristiansson E, Rutgersson C, Sturve J, Fick J, et al.
Environ Toxicol Chem. 2009

Gene expression in Fusarium graminearum grown on plant cell wall
Carapito R, Hatsch D, Vorwerk S, Petkovski E, Jeltsch JM and Phalip V
Fungal Genet. Biol. 2008

Transcription analysis using high-density micro- arrays of Aspergillus nidulans wild-type and creA mutant during growth on glucose or ethanol
Mogensen J, Nielsen HB, Hofmann G and Nielsen J
Fungal Genet. Biol. 2006

OligoWiz 2.0 – integrating sequence feature annotation into the design of microarray probes
Wernersson R and Nielsen HB
Nucleic Acids Res. 2005

New weakly expressed cell cycle-regulated genes in yeast
de Lichtenberg U, Wernersson R, Jensen TS, Nielsen HB, Fausbøll A et al.
Yeast 2005

Alternative splicing microarrays reveal functional expression of neuron-specific regulators in Hodkin lymphoma cells
Relógio A, Ben-Dov C, Baum M, Ruggiu M, Gemund C et al.
J. Biol. Chem. 2005

Characterization of an Escherichia coli elaC deletion mutant
Schilling O, Rüggeberg S, Vogel A, Rittner N, Weichert S et al.
Biochem. Biophys. Res. Commun. 2004

Validation of a novel, fully integrated and flexible microarray benchtop facility for gene expression profiling
Baum M, Bielau S, Rittner N, Schmid K, Eggelbusch K et al.
Nucleic Acids Res. 2003

A flexible and fully integrated system for amplification, detection and genotyping of genomic DNA targets based on microfluidic oligonucleotide arrays
Summerer D, Hevroni D, Jain A, Oldenburger A, Parker J et al.
New Biotechnology 2008

Mit der Geniom-Microarray-Technologie HPV-Genotypen auf der Spur
Schliwka J, Pullat J, Devilliers EM, Hoheisel JD and Beier M
BIOspektrum 2007

Arrayed primer extension on in situ synthesized 5´-3´- oligonucleotides in microchannels
Pullat J, Kusnezow W, Jaakson K, Beier M, Hoheisel JD and Metspalu A
New Biotechnology 2008

Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples
Pullat J, Fleischer R, Becker N, Beier M, Metspalu A and Hoheisel JD
BMC Genomics 2007